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home > depression center > depression a-z list > escitalopram index > escitalopram, lexapro drug monograph
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GENERIC NAME: escitalopram
BRAND NAME: Lexapro
DRUG CLASS AND MECHANISM: Escitalopram is an oral drug that is used
for treating depression and
generalized anxiety disorder. Chemically,
escitalopram is similar to citalopram (Celexa). Both are in the class of drugs
called selective serotonin reuptake inhibitors (SSRIs), a class that also
includes fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft). SSRIs
work by affecting neurotransmitters in the brain, the chemical messengers that
nerves use to communicate with one another. Neurotransmitters are made and
released by nerves and then travel to other nearby nerves where they attach to
receptors on the nerves. Some neurotransmitters that are released do not bind to
receptors and are taken up by the nerves that produced them. This is referred to
as "reuptake." Many experts believe that an imbalance of neurotransmitters is
the cause of depression. Escitalopram prevents the reuptake of one
neurotransmitter, serotonin, by nerves, an action which results in more
serotonin in the brain to attach to receptors. The FDA approved escitalopram in
August 2002.
PRESCRIPTION: Yes
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 5, 10, and 20 mg. Solution: 1 mg/ml
STORAGE: Escitalopram should be stored at room temperature, 15-30 C
(59-86 F)
PRESCRIBED FOR: Escitalopram is approved for the treatment of
depression and generalized anxiety disorder. Drugs in the SSRI class also have
been studied in persons with obsessive compulsive disorders and
panic disorders,
but escitalopram is not approved for this purpose.
DOSING: The usual starting dose of escitalopram is 10 mg once daily in
the morning or evening. The dose may be increased to 20 mg once daily after 1
week. Benefit may not be seen until treatment has been given for up to 4 weeks.
A daily dose of 20 mg may not be anymore effective than 10 mg daily for
treatment of depression. Escitalopram can be taken with or without food.
DRUG INTERACTIONS: All SSRIs, including escitalopram, should not be
combined with drugs in the monoamine oxidase (MAO) inhibitor class of
antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil),
tranylcypromine (Parnate), selegiline (Eldepryl) and
procarbazine (Matulane).
Such combinations may lead to confusion,
high blood pressure,
high fevers,
tremor or muscle rigidity, and increased activity. At least 14 days should
elapse after discontinuing escitalopram before starting an MAO inhibitor.
Conversely, at least 14 days should elapse after discontinuing an MAO inhibitor
before starting escitalopram.
Tryptophan can cause headaches, nausea, sweating,
and dizziness when taken with any SSRI.
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escitalopram Index
Glossary
escitalopram on RxList
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